Immunocap ISAC as an important diagnostic tool in rhino-sinusitis

Results The patient (smoker) complained on a variety of symptoms that were bothering her for more than 3 years: headaches, significant fatigue, nasal blockage, breathlessness on exercise and occasionally at rest. There were no ocular symptoms. She had several courses of antibiotics during this period with slight improvement. Careful history revealed progressive deterioration in her condition; there was no difference in her symptom pattern through the season although she noted that she had more sinus pains in winter. There was a dog, but no dampness in the house. There was no personal or family history of atopy. Anterior rhinoscopy had appearance of acute inflammation with no structural abnormalities. Spirometry showed FEV1 95%, FVC 92% and Peak flow 85% predicted. Skin prick test with valid controls, was negative to a standard panel of aeroallergens including dog. Immunocap ISAC test was offered to broaden the spectrum of allergens tested. This showed mono-sensitisation to Dog rCan f 5 Arginine esterase 1,5 ISU and negative to all other components.